Welcome To Arvigen Healthcare Generation towards healthcare bringing

Tuesday, December 18, 2018

Biomarker Risk Score May Identify Women at Risk for Gestational Diabetes

The predictive ability of a biomarker risk score beyond established risk factors may help identify women at risk of developing gestational diabetes (GDM) before conception and help with tailoring targeted prevention strategies, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Sylvia E. Badon, PhD, of the Division of Research at Kaiser Permanente Northern California in Oakland, point out that GDM is a common complication during pregnancy, occurring in 5% to 9% of pregnancies, and that GDM carries with it a number of long- and short-term consequences for mother and child, including increased risk of diabetes and cardiovascular disease in the mother and increased risk of diabetes in the child. The authors write that several biomarkers measure before pregnancy have been individually associated with the risk of GDM, but “previous studies have not examined the ability of multiple preconception biomarkers considered together, beyond established risk factors, to improve prediction of GDM. To the best of our knowledge, a preconception biomarker risk score has not yet been developed and assessed.” So the researchers aimed to develop a preconception biomarker risk score and test it to see how well it predicted GDM. From 1984 to 1996, female Kaiser Permanente Northern California members were invited to complete a comprehensive health examination [multiphasic health checkup (MHC)] upon enrollment. The researchers conducted a nested case-control study within the larger cohort of women who participated in the MHC. “Of the 27,743 women, 15- to 45-year-olds who participated in the MHC from 1984 to 1996, 4,098 subsequently became pregnant and gave birth before 31 December 2010; had questionnaire and clinical data, including serum samples, available; and were free of recognized diabetes,” the authors write. “Women diagnosed with GDM were considered cases. Two controls were selected for each case from among women who did not meet the GDM case definition during the study period.” For this study, 256 confirmed cases of GDM with valid biomarker measurements were included. High-risk levels of sex hormone-binding globulin (SHBG; <44.2 nM), glucose (>90 mg/dL), total adiponectin (<7.2 μg/mL), and homeostasis model assessment-estimated insulin resistance (HOMA-IR) (>3.9) were independently associated greater odds of GDM. “For each unit increase in the biomarker risk score, odds of GDM were 1.94 times greater (95% CI: 1.59, 2.36),” the authors write. “A biomarker risk score including only SHBG and glucose was sufficient to improve prediction beyond established risk factors (age, race/ethnicity, body mass index, family history of diabetes, previous GDM; area under the curve = 0.73 vs 0.67, P = 0.002).” Based on these results, the authors conclude that a preconception biomarker risk score, including SHBG, glucose, adiponectin, and HOMA-IR—measured, on average, 7 years before pregnancy—was associated with future GDM risk; however, a biomarker score, including only SHBG and glucose, may be sufficient to improve substantially the predictive ability for GDM beyond established GDM risk factors. The authors also note that lifestyle interventions have limited success in early pregnancy to prevent GDM, because the processes leading to GDM begin before pregnancy, as this study shows. “Identification of women at high risk for future GDM before pregnancy would allow for preconception interventions to attempt to alter the modifiable pathophysiologic pathways underlying the altered biomarker levels that we identified here,” the authors write.


  1. financial consultants in bangalore

    Education franchise is a major part of the franchise business and also a great opportunity to start your own business. There are all kinds of Education & training ...

  2. This particular papers fabulous, and My spouse and i enjoy each of the perform that you have placed into this. I’m sure that you will be making a really useful place. I has been additionally pleased. Good perform! Governance Risk and compliance

  3. Thank you again for all the knowledge you distribute,Good post. I was very interested in the article, it's quite inspiring I should admit. I like visiting you site since I always come across interesting articles like this one.Great Job, I greatly appreciate that.Do Keep sharing! Regards, tony of beverly

  4. I found so many interesting stuff in your blog especially its discussion. From the tons of comments on your articles, I guess I am not the only one having all the enjoyment here! keep up the good work... buy dormicum online

  5. Thank you for providing us with such a pleasant and informative blog. Ziyyara’s expert-led platform offers the finest online tuition for English in Saudi Arabia, specifically designed to cater to the needs of learners in Riyadh and beyond.
    For more info visit Online Tuition for english in Saudi Arabia or Call +971505593798, +919654271931

  6. Great information. The above content is very interesting to read. Looking for the best online phonics classes for kindergarten, Ziyyara Edutech’s online phonics classes for kindergarten are designed to conquer the challenges like limited hands-on activities and pronunciation issues with expert guidance.
    visit Online phonics classes fees

  7. Really great post, Thank you for sharing This knowledge.Excellently written article, Unlock academic excellence with Ziyyara Edutech's specialized online tuition for Class 11.
    For more info Contact us: +91-9654271931, +971-505593798 or visit Online tuition for 11th class


Study Shows MVT-602 Be a Novel Fertility-Improving Drug

  MVT-602 is a Novel Fertility-Improving Drug FERTILITY in women with reproductive health problems can be improved using a new drug accordin...